C3a 70-77( Complement 3a (70-77) )

Catalog No. M21018 CAS No. 63555-63-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

C3a 70-77
Note

Research use only, not for human use.
Brief Description

C3a 70-77 is an octapeptide corresponding to the COOH terminus of C3a.
Description

C3a 70-77 is an octapeptide corresponding to the COOH terminus of C3a.
In Vitro

The direct interaction of C3a(70-77) with human mononuclear leukocytes in culture results in a concentration-dependent inhibition of the generation of LIF evoked by mitogens and by the antigen SK-SD. The extent of suppression of LIF generation by C3a(70-77) is significant at concentrations of 10-7 M or higher and exceeds 75% at 10-6 M, irrespective of the stimulus. C3a (70-77) induces histamine release and degranulation of rat mast cells, promotes contraction of guinea pig ileal tissue, and enhances vascular permeability in human skin. C3a (70-77) selectively desensitizes ileal smooth muscle to C3a but not to human C5a, a related anaphylatoxin. Conversely, C3a-(70-77) is unable to contract ileal smooth muscle pretreated with natural C3a. This cross-desensitization indicates a specific interaction of C3a (70-77) with cellular C3a binding sites.
In Vivo

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Synonyms

Complement 3a (70-77)
Pathway

Immunology/Inflammation
Target

Complement System
Recptor

Complement system
Research Area

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Indication

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CAS Number

63555-63-5
Formula Weight

823.94
Molecular Formula

C35H61N13O10
Purity

>98% (HPLC)
Solubility

——
SMILES

CC(C)CC(NC(=O)CNC(=O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CO)NC(=O)C(C)N)C(=O)NC(C)C(=O)NC(CCCNC(=N)N)C(=O)O
Chemical Name

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1.Payan D. G . Modulation of human lymphocyte function by C3a and C3a(70-77)[J]. Journal of Experimental Medicine 1982 156(3):756-765.

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